Age-related macular degeneration (AMD) is a complex, multifactorial, progressive retinal
disease that affects millions of people worldwide and has become the leading cause of …

Delivery of genetic material to cells is an integral tool to analyze and reveal the genetic
interventions in normal cellular processes and differentiation, disease development and for …

Gene therapy has demonstrated enormous potential for changing how we combat disease.
By directly engineering the genetic composition of cells, it provides a broad range of options …

Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Coordinated changes of cellular plasticity and identity are critical for pluripotent
reprogramming and oncogenic transformation. However, the sequences of events that …

Neurons in the central nervous system (CNS) are terminally differentiated cells that
gradually lose their ability to support regeneration during maturation due to changes in …

Over the past decade, there has been a dramatic increase in efforts to ameliorate aging and
the diseases it causes, with transient expression of nuclear reprogramming factors recently …

The pollution of heavy metals (HMs) in the environment is a significant global environmental
issue, characterized by its extensive distribution, severe contamination, and profound …

While some animals, such as planaria and hydra, appear to be capable of seemingly
endless cycles of regeneration, most animals experience a gradual decline in fitness and …

Most age-related neurodegenerative diseases remain incurable owing to an incomplete
understanding of the disease mechanisms. Several environmental and genetic factors …