Tumor microenvironment in glioblastoma: Current and emerging concepts
P Sharma, A Aaroe, J Liang… - Neuro-Oncology …, 2023 - academic.oup.com
Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex
system, which in addition to cancer cells, consists of various resident brain and immune cells …
system, which in addition to cancer cells, consists of various resident brain and immune cells …
Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases
MK Skytthe, JH Graversen, SK Moestrup - International journal of …, 2020 - mdpi.com
The macrophage is a key cell in the pro-and anti-inflammatory response including that of the
inflammatory microenvironment of malignant tumors. Much current drug development in …
inflammatory microenvironment of malignant tumors. Much current drug development in …
CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma
The limited efficacy of immunotherapies against glioblastoma underscores the urgency of
better understanding immunity in the central nervous system. We found that treatment with …
better understanding immunity in the central nervous system. We found that treatment with …
Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity
Chemokines such as CC motif ligand 5 (CCL5) regulate immune cell trafficking in the tumor
microenvironment (TME) and govern tumor development, making them promising targets for …
microenvironment (TME) and govern tumor development, making them promising targets for …
Myeloid cells in glioblastoma microenvironment
Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …
Tumor-associated microglia and macrophages in the glioblastoma microenvironment and their implications for therapy
RS Andersen, A Anand, DSL Harwood, BW Kristensen - Cancers, 2021 - mdpi.com
Simple Summary Patients with glioblastoma—the most frequent and malignant primary brain
tumor—have a poor prognosis with a median survival of less than 15 months. Despite …
tumor—have a poor prognosis with a median survival of less than 15 months. Despite …
Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors
Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …
Glioblastoma immune landscape and the potential of new immunotherapies
T Daubon, A Hemadou, I Romero Garmendia… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma (GBM) are the most common tumors of the central nervous system and among
the deadliest cancers in adults. GBM overall survival has not improved over the last decade …
the deadliest cancers in adults. GBM overall survival has not improved over the last decade …
Epidemiology of brain and other CNS tumors
Abstract Purpose of Review Brain and other central nervous system (CNS) tumors, while
rare, cause significant morbidity and mortality across all ages. This article summarizes the …
rare, cause significant morbidity and mortality across all ages. This article summarizes the …
Translational landscape of glioblastoma immunotherapy for physicians: guiding clinical practice with basic scientific evidence
D Kreatsoulas, C Bolyard, BX Wu, H Cam… - Journal of Hematology & …, 2022 - Springer
Despite recent advances in cancer therapeutics, glioblastoma (GBM) remains one of the
most difficult cancers to treat in both the primary and recurrent settings. GBM presents a …
most difficult cancers to treat in both the primary and recurrent settings. GBM presents a …