Geroscience puts mechanisms of aging as a driver of the most common age-related
diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of …

Endocrine, nervous, and immune systems work coordinately to maintain the global
homeostasis of the organism. They show sex differences in their functions that, in turn …

Cancer survivors suffer from progressive frailty, multimorbidity, and premature morbidity. We
hypothesise that therapy-induced senescence and senescence progression via bystander …

Females and males often have markedly different mortality rates and life spans, but it is
unclear why these forms of sexual dimorphism evolve. The unguarded X hypothesis …

Limited resources affect an organism's physiology through the conserved metabolic
pathway, the mechanistic target of rapamycin (mTOR). Males and females often react …

An automated feeding system for the African killifish reveals the impact of diet on lifespan
and allows scalable assessment of a Page 1 McKay, Costa, Chen et al. eLife 2022;11:e69008 …

Male reproductive traits such as ejaculate size and quality, are expected to decline with
advancing age due to senescence. It is however unclear whether this expectation is upheld …

Males and females rarely express the same length of life. Here, we studied how sociosexual
exposure shapes male and female age-specific mortality rates in Drosophila melanogaster …

Background The progressive deregulation of the immune system with age, termed
immunosenescence, has been well studied in mammalian systems, but studies of immune …

Sex differences in human survival have been extensively investigated in many studies that
have in part uncovered the biological determinants that promote a longer life in females with …