[HTML][HTML] Artificial cells: from basic science to applications

C Xu, S Hu, X Chen - Materials Today, 2016 - Elsevier
Artificial cells have attracted much attention as substitutes for natural cells. There are many
different forms of artificial cells with many different definitions. They can be integral biological …

Functional consequences of developmentally regulated alternative splicing

A Kalsotra, TA Cooper - Nature Reviews Genetics, 2011 - nature.com
Genome-wide analyses of metazoan transcriptomes have revealed an unexpected level of
mRNA diversity that is generated by alternative splicing. Recently, regulatory networks have …

[HTML][HTML] Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma

MA Gillette, S Satpathy, S Cao, SM Dhanasekaran… - Cell, 2020 - cell.com
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …

[HTML][HTML] Integrated proteogenomic characterization of clear cell renal cell carcinoma

DJ Clark, SM Dhanasekaran, F Petralia, J Pan, X Song… - Cell, 2019 - cell.com
To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma
(ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic …

[HTML][HTML] Integrated proteogenomic characterization of human high-grade serous ovarian cancer

H Zhang, T Liu, Z Zhang, SH Payne, B Zhang… - Cell, 2016 - cell.com
To provide a detailed analysis of the molecular components and underlying mechanisms
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …

Global quantification of mammalian gene expression control

B Schwanhäusser, D Busse, N Li, G Dittmar… - Nature, 2011 - nature.com
Gene expression is a multistep process that involves the transcription, translation and
turnover of messenger RNAs and proteins. Although it is one of the most fundamental …

An expanded maize gene expression atlas based on RNA sequencing and its use to explore root development

SC Stelpflug, RS Sekhon, B Vaillancourt… - The plant …, 2016 - Wiley Online Library
Comprehensive and systematic transcriptome profiling provides valuable insight into
biological and developmental processes that occur throughout the life cycle of a plant. We …

Mitochondrial allostatic load puts the'gluc'back in glucocorticoids

M Picard, RP Juster, BS McEwen - Nature Reviews Endocrinology, 2014 - nature.com
The link between chronic psychosocial and metabolic stress and the pathogenesis of
disease has been extensively documented. Nevertheless, the cellular mechanisms by which …

Dynamic profiling of the protein life cycle in response to pathogens

M Jovanovic, MS Rooney, P Mertins, D Przybylski… - Science, 2015 - science.org
INTRODUCTION Mammalian gene expression is tightly controlled through the interplay
between the RNA and protein life cycles. Although studies of individual genes have shown …

[HTML][HTML] Human transcription factor protein interaction networks

H Göös, M Kinnunen, K Salokas, Z Tan, X Liu… - Nature …, 2022 - nature.com
Transcription factors (TFs) interact with several other proteins in the process of
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …