Background Prophylactic pinning of the uninvolved side after unilateral slipped capital
femoral epiphysis (SCFE) is controversial. The alpha angle, a measurement of femoral head …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung
cell types in health and disease is currently revolutionizing the identification of disease …

The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …

Molecular mechanisms of organismal and cell aging remain incompletely understood. We,
therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 …

In mammals, recent studies have demonstrated that the brain, the hypothalamus in
particular, is a key bidirectional integrator of humoral and neural information from peripheral …

Background Microbial inhabitants of soils are important to ecosystem and planetary
functions, yet there are large gaps in our knowledge of their diversity and ecology. The …

Objective The pathogenesis of Parkinson's disease (PD) involves complex interactions
between environmental and genetic factors. Metabolomics can shed light on alterations in …

Understanding aging is a grand challenge in biology. Exceptionally long-lived animals have
mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats …