Tumor neoantigen is the truly foreign protein and entirely absent from normal human
organs/tissues. It could be specifically recognized by neoantigen-specific T cell receptors …

Neoantigens are newly formed peptides created from somatic mutations that are capable of
inducing tumor-specific T cell recognition. Recently, researchers and clinicians have …

Preoperative MRI is one of the most important clinical results for the diagnosis and treatment
of glioma patients. The objective of this study was to construct a stable and validatable …

The transcriptomic classification of glioblastoma (GBM) has failed to predict survival and
therapeutic vulnerabilities. A computational approach for unbiased identification of core …

Association with hypomethylating agents is a promising strategy to improve the efficacy of
immune checkpoint inhibitors-based therapy. The NIBIT-M4 was a phase Ib, dose-escalation …

Microsatellite instability-high (MSI-H) tumors are characterized by high tumor mutation
burden and responsiveness to checkpoint blockade. We identified tumor-specific frameshifts …

Brain tumors (gliomas) are heterogeneous cellular ecosystems, where non-neoplastic
monocytic cells have emerged as key regulators of tumor maintenance and progression …

Background Glioblastoma (GBM) is a complex disease with extensive molecular and
transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors …

Glioblastomas are aggressive, fast-growing primary brain tumors. After standard-of-care
treatment with radiation in combination with temozolomide, the overall prognosis of newly …

Tumor progression is typically accompanied by an accumulation of driver and passenger
somatic mutations. A handful of those mutations occur in protein coding genes which …