The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

Age-associated changes in mitochondria are closely involved in aging. Apart from the
established roles in bioenergetics and biosynthesis, mitochondria are signaling organelles …

Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …

Aging is emerging as a druggable target with growing interest from academia, industry and
investors. New technologies such as artificial intelligence and advanced screening …

Abstract CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease
Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder …

Neurodegenerative disorders affect fifteen percent of the world's population and pose a
significant financial burden to all nations. Cognitive impairment is the seventh leading cause …

Insight on the underlying mechanisms of aging will advance our ability to extend healthspan,
treat age-related pathology and improve quality of life. Multiple genetic and pharmacological …

Current methods of high-throughput molecular and genomic analyses enabled to
reconstruct thousands of human molecular pathways. Knowledge of molecular pathways …

Introduction Aging is characterized by progressive metabolic dyshomeostasis that increases
morbidity and mortality. Solutions for optimizing healthy aging are challenged by lacking …

Angelica sinensis polysaccharide (ASP) is one of the principal active components of
Angelica sinensis (AS) that is widely used in natural medicine and has various …