Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study

WL Hamilton, R Amato, RW van der Pluijm… - The Lancet Infectious …, 2019 - thelancet.com
Background A multidrug-resistant co-lineage of Plasmodium falciparum malaria, named
KEL1/PLA1, spread across Cambodia in 2008–13, causing high rates of treatment failure …

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

A Mbengue, S Bhattacharjee, T Pandharkar, H Liu… - Nature, 2015 - nature.com
Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance
to them,, raises risk of wiping out recent gains achieved in reducing worldwide malaria …

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

KJ Wicht, S Mok, DA Fidock - Annual review of microbiology, 2020 - annualreviews.org
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …

Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda

PK Tumwebaze, MD Conrad, M Okitwi, S Orena… - Nature …, 2022 - nature.com
Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

BH Stokes, SK Dhingra, K Rubiano, S Mok, J Straimer… - Elife, 2021 - elifesciences.org
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …

Genetic architecture of artemisinin-resistant Plasmodium falciparum

O Miotto, R Amato, EA Ashley, B MacInnis… - Nature …, 2015 - nature.com
We report a large multicenter genome-wide association study of Plasmodium falciparum
resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast …

Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

C Amaratunga, P Lim, S Suon, S Sreng… - The Lancet infectious …, 2016 - thelancet.com
Summary Background Artemisinin resistance in Plasmodium falciparum threatens to reduce
the efficacy of artemisinin combination therapies (ACTs), thus compromising global efforts to …

Reflections on the 2021 World Malaria Report and the future of malaria control

A Monroe, NA Williams, S Ogoma, C Karema, F Okumu - Malaria Journal, 2022 - Springer
Abstract The World Malaria Report, released in December 2021, reflects the unique
challenges currently facing the global malaria community. The report showed the …

Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study

R Amato, P Lim, O Miotto, C Amaratunga… - The Lancet Infectious …, 2017 - thelancet.com
Background As the prevalence of artemisinin-resistant Plasmodium falciparum malaria
increases in the Greater Mekong subregion, emerging resistance to partner drugs in …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …