Links between COVID-19 and Parkinson's disease/Alzheimer's disease: reciprocal impacts, medical care strategies and underlying mechanisms

P Huang, LY Zhang, YY Tan, SD Chen - Translational Neurodegeneration, 2023 - Springer
The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with
neurodegenerative diseases and the specific neurological manifestations of COVID-19 have …

Apolipoprotein E and viral infection: Risks and Mechanisms

F Chen, Q Ke, W Wei, L Cui, Y Wang - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Apolipoprotein E (ApoE) is a multifunctional protein critical for lipid metabolism and
cholesterol homeostasis. In addition to being a well-known genetic determinant of both …

ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway

F Chen, Y Chen, Q Ke, Y Wang, Z Gong… - Journal of Translational …, 2023 - Springer
Background Recent numerous epidemiology and clinical association studies reported that
ApoE polymorphism might be associated with the risk and severity of coronavirus disease …

Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-β-associated pathology in APP/PS1 mouse model of Alzheimer's …

J Chen, J Chen, Z Lei, F Zhang, LH Zeng, X Wu… - Translational …, 2023 - nature.com
Although there are indications of a trend towards less severe acute respiratory symptoms
and a decline in overall lethality from the novel Coronavirus Disease 2019 (COVID-19) …

[HTML][HTML] Human genetic basis of severe or critical illness in COVID-19

XS Ji, B Chen, B Ze, WH Zhou - Frontiers in cellular and infection …, 2022 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality …

COVID-19 and the cardiovascular system: a study of pathophysiology and interpopulation variability

Y Zhao, X Han, C Li, Y Liu, J Cheng… - Frontiers in …, 2023 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans
can lead to various degrees of tissue and organ damage, of which cardiovascular system …

Targeted screening of genetic associations with COVID-19 susceptibility and severity

P Li, Y Ke, W Shen, S Shi, Y Wang, K Lin, X Guo… - Frontiers in …, 2022 - frontiersin.org
The COVID-19 pandemic has resulted in great morbidity and mortality worldwide and
human genetic factors have been implicated in the susceptibility and severity of COVID-19 …

Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virus

MT Pham, JY Lee, C Ritter, R Thielemann… - PLoS …, 2023 - journals.plos.org
Liver-generated plasma Apolipoprotein E (ApoE)-containing lipoproteins (LPs)(ApoE-LPs)
play central roles in lipid transport and metabolism. Perturbations of ApoE can result in …

Identification of receptors and factors associated with human coronaviruses in the oral cavity using single-cell RNA sequencing

F Gao, W Lin, X Wang, M Liao, M Zhang, N Qin, X Chen… - Heliyon, 2024 - cell.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) ravaged the
world, and Coronavirus Disease 2019 (COVID-19) exhibited highly prevalent oral symptoms …

[PDF][PDF] Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury

Y Mao, Y Chen, Y Li, L Ma, X Wang, Q Wang, A He… - Cell Reports, 2024 - cell.com
As a primary target of severe acute respiratory syndrome coronavirus 2, lung exhibits
heterogeneous histopathological changes following infection. However, comprehensive …