Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and
are increasingly used to track organisms along their life-course. This allows investigation …

Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …

Abstract The Human Ageing Genomic Resources (HAGR, http://genomics. senescence. info)
is a freely available online collection of research databases and tools for the biology and …

Pesticides inevitably enter aquatic environments, posing potential risks to organisms. The
common aquatic model organism, zebrafish (Danio rerio), are widely used to evaluate the …

DNA methylation is a major control program that modulates gene expression in a plethora of
organisms. Gene silencing through methylation occurs through the activity of DNA …

Pollution caused by volatile organic compounds (VOCs) and odorous pollutants in the air
can produce severe environmental problems. In recent years, the emission control of VOCs …

Background Recently, rapid improvements in technology and decrease in sequencing costs
have made RNA-Seq a widely used technique to quantify gene expression levels. Various …

Chronic inflammation is a prominent feature of aging and of common age‐related diseases,
including atherosclerosis, cancer and periodontitis. This volume examines modifiable risk …

Given the central role of DNA in life, and how ageing can be seen as the gradual and
irreversible breakdown of living systems, the idea that damage to the DNA is the crucial …