Population-based prospective studies, such as UK Biobank, are valuable for generating and
testing hypotheses about the potential causes of human disease. We describe how UK …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-
transcriptional gene silencing through base-pair binding on their target mRNAs. We …

Decline in biological resilience (ability to recover) is a key manifestation of aging that
contributes to increase in vulnerability to death with age eventually limiting longevity even in …

Inflammatory protein biomarkers induced by immune responses have been associated with
cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate …

Dravet syndrome is an archetypal rare severe epilepsy, considered 'monogenic', typically
caused by loss-of-function SCN1A variants. Despite a recognizable core phenotype, its …

Age-related changes to histone levels are seen in many species. However, it is unclear
whether changes to histone expression could be exploited to ameliorate the effects of …

Biological age (BA) is important for clinical monitoring and preventing aging-related
disorders and disabilities. Clinical and/or cellular biomarkers are measured and integrated …