Reduced activity of insulin/insulin-like growth factor signaling (IIS) extends health and life
span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in …

Alzheimer's disease (AD) is characterized by numerous sexual dimorphisms that impact the
development, progression, and probably the strategies to prevent and treat the most …

Objective COVID-19 might cause neuroinflammation in the brain, which could decrease
neurocognitive function. We aimed to evaluate the causal associations and genetic overlap …

The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

It is reported that overweight may lead to accelerated aging. However, there is still a lack of
evidence on the causal effect of overweight and aging. We collected genetic variants …

Abstract Background The American Heart Association introduced the Life's Simple 7
initiative to improve cardiovascular health by modifying cardiovascular risk factors and …

The disease criteria used by the World Health Organization (WHO) were applied to human
biological aging in order to assess whether aging can be classified as a disease. These …

Twin studies document leadership role occupancy (eg, whether one holds formal
supervisory or management positions) as a heritable trait. However, previous studies have …

The Apolipoprotein E (APOE) locus has garnered significant clinical interest because of its
association with Alzheimer's disease (AD) and longevity. This genetic association appears …

Alzheimer's disease (AD) is a devastating neurodegenerative condition with significant
genetic heritability. Several genes have been implicated in the onset of AD with the …