Frailty is a complex late life phenotype characterized by cumulative declines in multiple
physiological systems that increases the risk for disability and mortality. The biological …

The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public
health emergency. Increasing understanding about predisposing factors to infection and …

The genetics of human longevity has long been studied, and in this regard, centenarians
represent a very informative model. Centenarians are characterized by 2 main features: 1) …

Mirroring the obesity pandemic, nonalcoholic fatty liver disease (NAFLD) has become the
most common liver disease affecting populations worldwide. Approximately 30% of the adult …

The complex biological mechanisms underlying human brain aging remain incompletely
understood. This study investigated the genetic architecture of three brain age gaps (BAG) …

FOXO3 is a prominent longevity gene. To date, no-one has examined whether longevity-
associated FOXO3 genetic variants protect against mortality in all individuals, or only in …

Longevity is a complex phenotype influenced by both environmental and genetic factors.
The genetic contribution is estimated at about 25%. Despite extensive research efforts, only …

Abstract Machine learning models capable of predicting age given a set of inputs are
referred to as aging clocks. We recently developed an aging clock that utilizes 491 plasma …

Humans age at different rates and families with exceptional longevity provide an opportunity
to understand why some people age slower than others. Unique features exhibited by …

Introduction Fibroblast growth factor 23 (FGF23), a potential biomarker for kidney function, is
related to cardiovascular disease (CVD) and diabetes, although it is unclear whether the …