The increasing number of older people is resulting in an increased prevalence of age-
related diseases. Research has shown that the ageing process itself is a potential point of …

We conducted a genome-wide association study of 1320 centenarians from the New
England Centenarian Study (median age= 104 years) and 2899 unrelated controls using> 9 …

Despite enormous research efforts, the genetic component of longevity has remained largely
elusive. The investigation of common variants, mainly located in intronic or regulatory …

Somatic mutations accumulate with age and are associated closely with human health, their
characterization in longevity cohorts remains largely unknown. Here, by analyzing whole …

The familial resemblance in length of adult life is very modest. Studies of parent‐offspring
and twins suggest that exceptional health and survival have a stronger genetic component …

We performed a genome-wide association study (GWAS) of human extreme longevity (EL),
defined as surviving past the 99th survival percentile, by aggregating data from four …

Transcriptome-wide association studies (TWASs) are a powerful approach to identify genes
whose expression is associated with complex disease risk. However, non-causal genes can …

The world population is getting older and studies aiming to enhance our comprehension of
the underlying mechanisms responsible for health span are of utmost interest for longevity …

Background A variety of factors, including diet and lifestyle, obesity, physiology, metabolism,
hormone levels, psychology, and inflammation, have been associated with longevity. The …

Background Cognitive impairment is an irreversible, aging-associated condition that robs
people of their independence. The purpose of this study was to investigate possible causes …