Aging and neurodegenerative diseases share common hallmarks, including mitochondrial
dysfunction and protein aggregation. Moreover, one of the major issues of the demographic …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

Compelling evidence from basic molecular biology has demonstrated the dual roles of
microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are …

Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

Abstract Machine learning has been used in the past for the auxiliary diagnosis of
Alzheimer's Disease (AD). However, most existing technologies only explore single-view …

Neurodegenerative diseases are a growing health concern. The increasing incidences of
these disorders have a great impact on the patients' quality of life. Although the mechanisms …

The search for immune biomarkers in psychiatric disorders has primarily focused on pro-
inflammatory cytokines. Other immune proteins including chemokines have been relatively …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by the
deposition of extracellular aggregates of amyloid-β (Aβ), the formation of intraneuronal tau …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

A series of multitarget-directed resveratrol derivatives was designed and synthesized for the
treatment of Alzheimer's disease (AD). In vitro studies indicated that most of the target …