Systematic evaluations of doxorubicin-induced toxicity in rats based on metabolomics

C Geng, C Cui, C Wang, S Lu, M Zhang, D Chen… - ACS …, 2020 - ACS Publications
Doxorubicin (DOX) is widely used to treat solid tumors, but its use is limited by its severe
cardiotoxicity, nephrotoxicity, hepatotoxicity, and neurotoxicity. Metabolomic studies on DOX …

[HTML][HTML] How do metabolic processes age: Evidence from human metabolomic studies

O Robinson, CHE Lau - Current Opinion in Chemical Biology, 2023 - Elsevier
Metabolomics, the global profiling of small molecules in the body, has emerged as a
promising analytical approach for assessing molecular changes associated with ageing at …

[HTML][HTML] Molecular Research on Stress Responses in Quercus spp.: From Classical Biochemistry to Systems Biology through Omics Analysis

M Escandón, MÁ Castillejo, JV Jorrín-Novo, MD Rey - Forests, 2021 - mdpi.com
The genus Quercus (oak), family Fagaceae, comprises around 500 species, being one of
the most important and dominant woody angiosperms in the Northern Hemisphere …

[HTML][HTML] The aging process: A metabolomics perspective

A Castro, ÉF Signini, JM De Oliveira… - Molecules, 2022 - mdpi.com
Aging process is characterized by a progressive decline of several organic, physiological,
and metabolic functions whose precise mechanism remains unclear. Metabolomics allows …

Influence of Age, Sex, and Diet on the Human Fecal Metabolome Investigated by 1H NMR Spectroscopy

M Cui, A Trimigno, V Aru, MA Rasmussen… - Journal of Proteome …, 2021 - ACS Publications
The human fecal metabolome is increasingly studied to explore the impact of diet and
lifestyle on health and the gut microbiome. However, systematic differences and …

[HTML][HTML] Metabolomic profiles associated with physical activity in White and African American adult men

Y Du, YY Li, BY Choi, R Fernadez, KJ Su, K Sharma… - Plos one, 2023 - journals.plos.org
Background Physical activity (PA) is associated with various health benefits, especially in
improving chronic health conditions. However, the metabolic changes in host metabolism in …

Metabolomics and metabolites in ischemic stroke

MS Chumachenko, TV Waseem… - Reviews in the …, 2022 - degruyter.com
Stroke is a major reason for disability and the second highest cause of death in the world.
When a patient is admitted to a hospital, it is necessary to identify the type of stroke, and the …

[HTML][HTML] The prevalence and predictors of geriatric giants in community-dwelling older adults: a cross-sectional study from the Middle East

SZ Badrkhahan, M Ala, H Fakhrzadeh, A Yaghoobi… - Scientific Reports, 2023 - nature.com
The term “geriatric giants” refers to the chronic disabilities of senescence leading to adverse
health outcomes. This study aimed to investigate the prevalence and predictors of geriatric …

[HTML][HTML] The urinary metabolome of healthy newborns

Y López-Hernández, JJ Oropeza-Valdez… - Metabolites, 2020 - mdpi.com
The knowledge of normal metabolite values for neonates is key to establishing robust cut-off
values to diagnose diseases, to predict the occurrence of new diseases, to monitor a …

Metabolites in aging and aging‐relevant diseases: Frailty, sarcopenia and cognitive decline

H Kondoh, M Kameda - Geriatrics & Gerontology International, 2024 - Wiley Online Library
Aging shows biologically complex features with high individual variability, which reflects the
exposure to several stimuli and the adaptation to them. Among them, metabolic changes are …