The role of the tumor microenvironment (TME) in the progression of colorectal cancer (CRC)
and its acquisition of resistance to treatment become the research hotspots. As an important …

Currently, there is a crucial need for novel diagnostic and prognostic biomarkers with high
specificity and sensitivity in patients with colorectal cancer. A “liquid biopsy” is characterized …

Long‐read sequencing (LRS) has been around for more than a decade, but widespread
adoption of the technology has been slow due to the perceived high error rates and high …

Background Plasma cell-free DNA (cfDNA) methylation has shown the potential in the
detection and prognostic testing in multiple cancers. Herein, we thoroughly investigate the …

Colorectal carcinoma (CRC) is the third most common cancer in terms of diagnosis and the
second in terms of mortality. Recent studies have shown that various proteins, such as …

Background The feasibility of DNA methylation-based assays in detecting minimal residual
disease (MRD) and postoperative monitoring remains unestablished. We aim to investigate …

Colorectal cancer (CRC) is the third most common fatal cancer worldwide, accounting for≈
10% of cancer‐related mortality. Metabolic shift occurs from the very early stage during the …

Simple Summary ctDNA is a small DNA fragment derived from tumor cells, which contains
tumor-related genomic information, such as mutation, methylation, microsatellite instability …

An effective blood-based method for the diagnosis of colorectal cancer has not yet been
developed. Molecular alterations of immune cells occur early in tumorigenesis, providing the …

Simple Summary Liquid biopsies provide a non-invasive means to diagnose and profile
tumors when tissue is not available. Sequence-based analysis of cell-free DNA (cfDNA) is …