F-box protein 43 promoter methylation as a novel biomarker for hepatitis B virus-associated hepatocellular carcinoma

Y Zhang, JW Wang, X Su, JE Li, XF Wei… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) has a high prevalence and poor prognosis
worldwide. Therefore, it is urgent to find effective and timely diagnostic markers. The …

[HTML][HTML] VSOLassoBag: a variable-selection oriented LASSO bagging algorithm for biomarker discovery in omic-based translational research

J Liang, C Wang, D Zhang, Y Xie, Y Zeng, T Li… - Journal of Genetics and …, 2023 - Elsevier
Screening biomolecular markers from high-dimensional biological data is one of the long-
standing tasks for biomedical translational research. With its advantages in both feature …

Discovery and validation of methylation signatures in circulating cell-free DNA for early detection of esophageal cancer: a case-control study

G Qiao, W Zhuang, B Dong, C Li, J Xu, G Wang, L Xie… - BMC medicine, 2021 - Springer
Background Plasma cell-free DNA (cfDNA) methylation has shown promising results in the
early detection of multiple cancers recently. Here, we conducted a study to investigate the …

Liquid biopsy in colorectal carcinoma: clinical applications and challenges

D Kolenčík, SN Shishido, P Pitule, J Mason, J Hicks… - Cancers, 2020 - mdpi.com
Colorectal carcinoma (CRC) is characterized by wide intratumor heterogeneity with general
genomic instability and there is a need for improved diagnostic, prognostic, and therapeutic …

Individualized dynamic methylation-based analysis of cell-free DNA in postoperative monitoring of lung cancer

K Chen, G Kang, Z Zhang, A Lizaso, S Beck, I Lyskjær… - BMC medicine, 2023 - Springer
Background The feasibility of DNA methylation-based assays in detecting minimal residual
disease (MRD) and postoperative monitoring remains unestablished. We aim to investigate …

Molecular cancer screening: in search of evidence

S Raoof, CJ Kennedy, DA Wallach, A Bitton… - Nature Medicine, 2021 - nature.com
Molecular cancer screening: in search of evidence | Nature Medicine Skip to main content
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Saliva biopsy: detecting the difference of EBV DNA methylation in the diagnosis of nasopharyngeal carcinoma

XH Zheng, CM Deng, T Zhou, XZ Li… - … Journal of Cancer, 2023 - Wiley Online Library
Saliva sampling is a non‐invasive method, and could be performed by donors themselves.
However, there are few studies reporting biomarkers in saliva in the diagnosis of NPC. A …

[HTML][HTML] Big data-driven precision medicine: Starting the custom-made era of iatrology

C Song, Y Kong, L Huang, H Luo, X Zhu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Precision medicine is a new therapeutic concept and method emerging in recent years. The
rapid development of precision medicine is driven by the development of omics related …

Clinical applications of circulating tumor cells and circulating tumor DNA as a liquid biopsy marker in colorectal cancer

I Heidrich, TSA Abdalla, M Reeh, K Pantel - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer is one of the most frequent malignant tumors worldwide
and the spread of tumor cells through the blood circulation followed by the colonization of …

Circulating NPTX2 methylation as a non-invasive biomarker for prognosis and monitoring of metastatic pancreatic cancer

MV García-Ortiz, P Cano-Ramírez… - Clinical …, 2023 - Springer
Background Pancreatic cancer is the most lethal cancer with a dismal prognosis mainly due
to diagnosis at advanced stage and ineffective treatments. CA19-9 levels and computed …