Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Objective To assess the association between leucocyte telomere length and risk of
cardiovascular disease. Design Systematic review and meta-analysis. Data sources Studies …

Telomere attrition is associated with increased morbidity and mortality of various age-related
diseases. Reports of association between telomere length (TL) and all-cause mortality …

Stem cell ageing underlies the ageing of tissues, especially those with a high cellular
turnover. There is growing evidence that the ageing of the immune system is initiated at the …

To determine the most important drivers of successful ageing at extreme old age, we
combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health …

Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …

The attrition of telomeres, the ends of eukaryote chromosomes, is thought to play an
important role in cell deterioration with advancing age. The observed variation in telomere …

Background—Telomeres are repetitive, gene-poor regions that cap the ends of DNA and
help maintain chromosomal integrity. Their shortening is caused by inflammation and …

Telomere length (TL) has been associated with aging and mortality, but individual
differences are also influenced by genetic factors, with previous studies reporting heritability …

The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …