Ageing and rejuvenation of tissue stem cells and their niches

A Brunet, MA Goodell, TA Rando - Nature Reviews Molecular Cell …, 2023 - nature.com
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Control of satellite cell function in muscle regeneration and its disruption in ageing

P Sousa-Victor, L García-Prat… - … Reviews Molecular Cell …, 2022 - nature.com
Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

[HTML][HTML] Metabolic changes in aging humans: current evidence and therapeutic strategies

AK Palmer, MD Jensen - The Journal of clinical …, 2022 - Am Soc Clin Investig
Aging and metabolism are inextricably linked, and many age-related changes in body
composition, including increased central adiposity and sarcopenia, have underpinnings in …

[HTML][HTML] ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression

S Zhang, F Yang, Y Huang, L He, Y Li, YCE Wan… - Nature …, 2023 - nature.com
Skeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining
muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly …

[HTML][HTML] Molecular mechanisms of exercise contributing to tissue regeneration

J Chen, R Zhou, Y Feng, L Cheng - Signal Transduction and Targeted …, 2022 - nature.com
Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

[HTML][HTML] Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging

DI Benjamin, JO Brett, P Both, JS Benjamin, HL Ishak… - Cell metabolism, 2023 - cell.com
With age, skeletal muscle stem cells (MuSCs) activate out of quiescence more slowly and
with increased death, leading to defective muscle repair. To explore the molecular …

Engineered meatballs via scalable skeletal muscle cell expansion and modular micro-tissue assembly using porous gelatin micro-carriers

Y Liu, R Wang, S Ding, L Deng, Y Zhang, J Li, Z Shi… - Biomaterials, 2022 - Elsevier
The emerging field of cultured meat faces several technical hurdles, including the scale-up
production of quality muscle and adipose progenitor cells, and the differentiation and …

[HTML][HTML] Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation

KA Murach, CS Fry, EE Dupont‐Versteegden… - The FASEB …, 2021 - ncbi.nlm.nih.gov
Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways.
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …

[HTML][HTML] Key signaling pathways in aging and potential interventions for healthy aging

M Yu, H Zhang, B Wang, Y Zhang, X Zheng, B Shao… - Cells, 2021 - mdpi.com
Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …