When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity of …

Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-
1), declines over time until only low levels can be detected in individuals aged≥ 60 years …

Rapamycin, an inhibitor of m TOR kinase, increased median lifespan of genetically
heterogeneous mice by 23%(males) to 26%(females) when tested at a dose threefold higher …

Abstract The Free Radical Theory of Ageing, was first proposed by Denham Harman in the
mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At …

Aging is inevitable, but the inherently and genetically programmed aging process is
markedly influenced by environmental factors. All organisms are constantly exposed to …

Genetic overexpression of protein deacetylase Sir2 increases longevity in a variety of lower
organisms, and this has prompted interest in the effects of its closest mammalian …

MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In
contrast, we find that Myc haploinsufficient (Myc+/–) mice exhibit increased lifespan. They …

Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

The oxidative stress theory of aging predicts that manipulations that alter oxidative
stress/damage will alter aging. The gold standard for determining whether aging is altered is …

Growth hormone (GH) is a key determinant of postnatal growth and plays an important role
in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling …