Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …

Single-cell multi-omics has recently emerged as a powerful technology by which different
layers of genomic output—and hence cell identity and function—can be recorded …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue
dysfunction and disease. At the cellular level, ageing is associated with reduced function …

Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …

The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can
convert somatic differentiated cells into pluripotent stem cells in a process known as …

The aging process results in significant epigenetic changes at all levels of chromatin and
DNA organization. These include reduced global heterochromatin, nucleosome remodeling …