The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

Numerous viruses use specialized surface molecules called fusogens to enter host cells.
Many of these viruses, including the severe acute respiratory syndrome coronavirus 2 …

Despite tremendous advancements in technologies and resources, drug discovery still
remains a tedious and expensive process. Though most cells are cultured using 2D …

COVID-19 is linked to endotheliopathy and coagulopathy, which can result in multi-organ
failure. The mechanisms causing endothelial damage due to severe acute respiratory …

Understanding mechanisms and manifestations of cardiovascular risk factors, including
diabetes, on vascular cells such as endothelial cells, pericytes, and vascular smooth muscle …

SARS-CoV-2 infection can cause persistent respiratory sequelae. However, the underlying
mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 …

Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is
challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives …

Nirmatrelvir is the main component of Paxlovid, an oral antiviral drug approved for the
treatment of COVID-19 caused by SARS-COV-2 infection. Nirmatrelvir targets the main …

The rapid and high precision analysis of SARS-CoV-2 RNA in saliva is crucial for the
efficient prevention and control of COVID-19. Herein, we developed a novel ratiometric …