Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series
of genetic pathways have been discovered to regulate lifespan in model organisms …

Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …

An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …

Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics has undergone
dramatic developments over the past decade. This review focuses on state of the art in LC …

Given the dramatic increase in ageing populations, it is of great importance to understand
the genetic and molecular determinants of healthy ageing and longevity. Semi …

Understanding how metabolites are longitudinally influenced by age and sex could facilitate
the identification of metabolomic profiles and trajectories that indicate disease risk. We …

Sphingomyelin (SM) is a dominant sphingolipid in membranes of mammalian cells and this
lipid class is specifically enriched in the plasma membrane, the endocytic recycling …

Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease.
Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that …