Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …

Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …

Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …

Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …

As aging societies in the western world face a growing prevalence of vascular cognitive
impairment and Alzheimer's disease (AD), understanding their underlying causes and …

Robust biomarkers of chronological age have been developed in humans and model
mammalian species such as rats and mice using DNA methylation data. The concept of …