From genome-wide associations to candidate causal variants by statistical fine-mapping
Advancing from statistical associations of complex traits with genetic markers to
understanding the functional genetic variants that influence traits is often a complex process …
understanding the functional genetic variants that influence traits is often a complex process …
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
DI Swerdlow, KB Kuchenbaecker… - International journal …, 2016 - academic.oup.com
Mendelian randomization (MR) studies typically assess the pathogenic relevance of
environmental exposures or disease biomarkers, using genetic variants that instrument …
environmental exposures or disease biomarkers, using genetic variants that instrument …
Improving power and accuracy of genome-wide association studies via a multi-locus mixed linear model methodology
Genome-wide association studies (GWAS) have been widely used in genetic dissection of
complex traits. However, common methods are all based on a fixed-SNP-effect mixed linear …
complex traits. However, common methods are all based on a fixed-SNP-effect mixed linear …
An efficient multi-locus mixed-model approach for genome-wide association studies in structured populations
Population structure causes genome-wide linkage disequilibrium between unlinked loci,
leading to statistical confounding in genome-wide association studies. Mixed models have …
leading to statistical confounding in genome-wide association studies. Mixed models have …
Methodological implementation of mixed linear models in multi-locus genome-wide association studies
YJ Wen, H Zhang, YL Ni, B Huang… - Briefings in …, 2018 - academic.oup.com
The mixed linear model has been widely used in genome-wide association studies (GWAS),
but its application to multi-locus GWAS analysis has not been explored and assessed. Here …
but its application to multi-locus GWAS analysis has not been explored and assessed. Here …
Iterative sure independence screening EM-Bayesian LASSO algorithm for multi-locus genome-wide association studies
CL Tamba, YL Ni, YM Zhang - PLoS computational biology, 2017 - journals.plos.org
Genome-wide association study (GWAS) entails examining a large number of single
nucleotide polymorphisms (SNPs) in a limited sample with hundreds of individuals, implying …
nucleotide polymorphisms (SNPs) in a limited sample with hundreds of individuals, implying …
Prediction of Alzheimer's disease using blood gene expression data
Identification of AD (Alzheimer's disease)-related genes obtained from blood samples is
crucial for early AD diagnosis. We used three public datasets, ADNI, AddNeuroMed1 …
crucial for early AD diagnosis. We used three public datasets, ADNI, AddNeuroMed1 …
[HTML][HTML] Evaluation of the lasso and the elastic net in genome-wide association studies
P Waldmann, G Mészáros, B Gredler, C Fuerst… - Frontiers in …, 2013 - frontiersin.org
The number of publications performing genome-wide association studies (GWAS) has
increased dramatically. Penalized regression approaches have been developed to …
increased dramatically. Penalized regression approaches have been developed to …
Association mapping in plants in the post-GWAS genomics era
PK Gupta, PL Kulwal, V Jaiswal - Advances in genetics, 2019 - Elsevier
With the availability of DNA-based molecular markers during early 1980s and that of
sophisticated statistical tools in late 1980s and later, it became possible to identify genomic …
sophisticated statistical tools in late 1980s and later, it became possible to identify genomic …
Genetic diversity in tomato (Solanum lycopersicum) and its wild relatives
Tomato, ranking 1st in the world for vegetables, accounts for 14% of world vegetable
production (over 100 million metric tons/year $1.6 billion market;(Food and Agriculture …
production (over 100 million metric tons/year $1.6 billion market;(Food and Agriculture …