For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

Spatial transcriptomics technologies developed in recent years can provide various
information including tissue heterogeneity, which is fundamental in biological and medical …

Tissues are complex environments where different cell types are in constant interaction with
each other and with non-cellular components. Preserving the spatial context during …

Single-cell and spatial transcriptomics have diverted researchers' attention from the
multicellular level to the single-cell level and spatial information. Single-cell transcriptomes …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Spatial transcriptomics (ST) methods unlock molecular mechanisms underlying tissue
development, homeostasis, or disease. However, there is a need for easy-to-use, high …

Macrophages, as pivotal cells within the tumour microenvironment, significantly influence
the impact of and reactions to treatments for solid tumours. The rapid evolution of …

Adding anti–programmed cell death protein 1 (anti–PD-1) to 5-fluorouracil (5-FU)/platinum
improves survival in some advanced gastroesophageal adenocarcinomas (GEA). To …

Gastrointestinal cancer remains a significant global health burden. The pursuit of advancing
the comprehension of tumorigenesis, along with the identification of reliable biomarkers and …

Single-cell and spatial molecular profiling assays have shown large gains in sensitivity,
resolution and throughput. Applying these technologies to specimens from human and …