Objectives Anxiety is an increasingly recognised predictor of cognitive deterioration in older
adults and in those with mild cognitive impairment. Often believed to be a prodromal feature …

Background: Stress is a common reaction to an environmental adversity, but a dysregulation
of the stress response can lead to psychiatric illnesses such as major depressive disorder …

Air pollution is regarded as an important risk factor for many diseases that affect a large
proportion of the human population. To date, accumulating reports have noted that …

O cenário da pandemia de COVID-19 representa um desafio sem precedentes para a
sociedade. Em que pese a importância das medidas imediatas visando à prevenção da …

Telomeres play an important part in aging and show relationships to lifetime adversity,
particularly childhood adversity. Meta-analyses demonstrate reliable associations between …

Measurement of anxiety is desirable for the benefit of drug development and understanding
the brain function and mental well-being. Animal models offer the advantages of detailed …

Introduction: Anxiety disorders manifest in women more than in men by almost twofold. This
narrative review aims to summarize the sex-related biological factors, which underpin …

The pathophysiological underpinnings of neuroprogressive processes in recurrent major
depressive disorder (rMDD) are reviewed. A wide array of biochemical processes underlie …

Older adults with anxiety have lower gray matter brain volume—a component of accelerated
aging. We have previously validated a machine learning model to predict brain age, an …

Telomerase, a specialized ribonucleoprotein enzyme complex, maintains telomere length at
the 3′ end of chromosomes, and functions importantly in stem cells, cancer and aging …