L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion
chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the …

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Abnormal α-synuclein aggregation is a key pathological feature of a group of
neurodegenerative diseases known as synucleinopathies, which include Parkinson's …

In the last decade, emerging evidence has reported correlations between the gut
microbiome and human health and disease, including those affecting the brain. We …

Background Parkinson's disease (PD) is a prevalent neurological disease in the elderly with
increasing morbidity and mortality. Despite enormous efforts, rapid and accurate diagnosis …

Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …

Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria.
Nonetheless, it is avidly taken up from the diet by humans and other animals through a …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the
central nervous system (CNS), which affects mostly older adults. In recent years, the …

There has been a recent surge of interest in the unique low molecular weight dietary
thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from …

Parkinson's disease is a neurodegenerative disorder characterized by the accumulation of
intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several …