Gut microbiota and metabolome alterations associated with Parkinson's disease

S Vascellari, V Palmas, M Melis, S Pisanu, R Cusano… - Msystems, 2020 - Am Soc Microbiol
Parkinson's disease is a neurodegenerative disorder characterized by the accumulation of
intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several …

Gut microenvironmental changes as a potential trigger in Parkinson's disease through the gut–brain axis

SJ Chen, CH Lin - Journal of biomedical science, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease attributed
to the synergistic effects of genetic risk and environmental stimuli. Although PD is …

Diet-derived antioxidants: the special case of ergothioneine

B Halliwell, RMY Tang, IK Cheah - Annual Review of Food …, 2023 - annualreviews.org
This article reviews what is presently known about the biological roles of the diet-derived
compound ergothioneine (ET). ET seems important to humans because it is rapidly taken up …

A microbial transporter of the dietary antioxidant ergothioneine

DG Dumitrescu, EM Gordon, Y Kovalyova… - Cell, 2022 - cell.com
Summary Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for
the maintenance of intracellular redox homeostasis. However, many host-associated …

[HTML][HTML] Bio-funcional components in mushrooms, a health opportunity: Ergothionine and huitlacohe as recent trends

GA Martinez-Medina, ML Chávez-González… - Journal of Functional …, 2021 - Elsevier
Macrofungi, mushrooms or higher fungi have been employed for medicinal and food
purposes for decades, nevertheless, also represent, a novel and fruitful source of …

Lipid pathway dysfunction is prevalent in patients with Parkinson's disease

J Galper, NJ Dean, R Pickford, SJG Lewis, GM Halliday… - Brain, 2022 - academic.oup.com
Many genetic risk factors for Parkinson's disease have lipid-related functions and lipid-
modulating drugs such as statins may be protective against Parkinson's disease. Moreover …

Gut microbiota-derived metabolites and their importance in neurological disorders

NM Swer, BS Venkidesh, TS Murali… - Molecular Biology …, 2023 - Springer
Microbial-derived metabolites are the intermediate or end products of bacterial digestion.
They are one of the most important molecules for the gut to connect with the brain …

[HTML][HTML] Ergothioneine and its prospects as an anti-ageing compound

Y Apparoo, CW Phan, UR Kuppusamy… - Experimental …, 2022 - Elsevier
Healthy ageing is a crucial process that needs to be highlighted as it affects the quality of
lifespan. An increase in oxidative stress along with ageing is the major factor related to the …

Alternations of metabolic profile and kynurenine metabolism in the plasma of Parkinson's disease

KH Chang, ML Cheng, HY Tang, CY Huang… - Molecular …, 2018 - Springer
The pathogenesis of Parkinson's disease (PD) remains to be elucidated. Metabolomic
analysis has the potential to identify biochemical pathways and metabolic profiles that are …

Metabolic biomarkers and neurodegeneration: a pathway enrichment analysis of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis

M Kori, B Aydın, S Unal, KY Arga… - Omics: a journal of …, 2016 - liebertpub.com
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
and amyotrophic lateral sclerosis (ALS) lack robust diagnostics and prognostic biomarkers …