The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal
function. Altered TRP metabolism has been implicated in the pathophysiology of various …

Low blood concentrations of the diet-derived compound ergothioneine (ET) have been
associated with cognitive impairment and cerebrovascular disease (CeVD) in cross …

Ergothioneine (ET) is a dietary amino-thione with strong antioxidant and cytoprotective
properties and has possible therapeutic potential for neurodegenerative and vascular …

Bilirubin is one of the most frequently measured metabolites in medicine, yet its physiologic
roles remain unclear. Bilirubin can act as an antioxidant in vitro, but whether its redox activity …

Introduction Parkinson's disease (PD) is a multisystem disorder of unknown etiology,
highlights a broad array of symptoms and pathological features influencing organs …

The plasma of Parkinson's disease (PD) patients may contain various altered metabolites
associated with the risk or progression of the disease. Characterization of the abnormal …

Significance: Ergothioneine (ET) is an unusual sulfur-containing amino acid derived from
histidine, acquired predominantly from food. Its depletion is associated with deleterious …

The lack of knowledge about the onset and progression of Parkinson's disease (PD)
hampers its early diagnosis and treatment. Metabolomics might shed light on the PD imprint …

Objective To investigate the kinetics and metabolism of caffeine in serum from patients with
Parkinson disease (PD) and controls using liquid chromatography–mass spectrometry …

Objective To profile the amine/phenol submetabolome to determine potential metabolite
biomarkers associated with Parkinson's disease (PD) and PD with incipient dementia …