Cancer incidence increase has multiple aetiologies. Mutant alleles accumulation in
populations may be one of them due to strong heritability of many cancers. The opportunity …

Significance: The p53 tumor suppressor has been dubbed the “guardian of genome”
because of its various roles in the response to DNA damage such as DNA damage repair …

The medicinal plant Luffa operculata (L.) Cogn. has therapeutic properties in the treatment of
sinusitis, rhinitis and abortifacient conditions. Ethnopharmacological studies report that the …

DNA repair is responsible for maintaining the integrity of the genome. Perturbations in the
DNA repair pathways have been identified in several human cancers. Thus, compounds …

Abstract Activation of PI3K/AKT signalling by PTEN loss significantly enhances
chemoresistance in bladder cancer. This study aims to evaluate PTEN regulation and …

Drug resistance is a major impediment in cancer therapy which strongly reduces the
efficiency of anti-cancer drugs. Exosomes are extracellular vesicles with cup or spherical …

Multidrug resistance (MDR) is one of the key barriers in chemotherapy, leading to the
generation of insensitive cancer cells towards administered therapy. Genetic and epigenetic …

DNA damage/repair constitutes several key pathways working in concert to eliminate DNA
lesions and maintain genome stability and integrity. Defective components in DNA damage …

Genomes are continually subjected to DNA damage whether they are induced from intrinsic
physiological processes or extrinsic agents. Double-stranded breaks (DSBs) are the most …

The DNA damage response (DDR) plays crucial roles in cancer prevention and therapy.
Poly (ADP-ribose) polymerase 1 (PARP1) mediates multiple signal transduction in the DDR …