Interindividual variability in DNA damage response (DDR) dynamics may evoke differences
in susceptibility to cancer. However, pathway dynamics are often studied in cell lines as …

The phenomenon of drug resistance has been a hindrance to therapeutic medicine since
the late 1940s. There is a plethora of factors and mechanisms contributing to progression of …

Cancer is pervasive across multicellular species, but what explains differences in cancer
prevalence across species? Using 16,049 necropsy records for 292 species spanning three …

Nonmelanoma skin cancer (NMSC) is the most common cancer worldwide and the
incidence continues to rise, in part due to increasing numbers in high-risk groups such as …

Poly (ADP‐ribose) polymerase (PARP) inhibitors have proven to be successful agents in
inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached …

DNA in cells is frequently damaged by endogenous and exogenous agents. However,
comprehensive mechanisms to combat and repair DNA damage have evolved to ensure …

Abstract CDK2 (cyclin-dependent kinase 2), a member of the CDK family, has been shown
to play a role in many cellular activities including cell cycle progression, apoptosis and …

Rad50 is a component of MRN (Mre11‐Rad50‐Nbs1), which participates in DNA double‐
strand break repair and DNA‐damage checkpoint activation. Here, we sought to investigate …

Cancer cells are commonly in a state of redox imbalance that drives their growth and
survival. To compensate for oxidative stress induced by the tumor redox environment …

The first-line chemotherapy of colorectal cancer (CRC), besides surgery, comprises
administration of 5-Fluorouracil (5FU). Apart from cytotoxic effect on cancer cells, 5FU may …