Circulating pre-microRNA-488 in peripheral blood is a potential biomarker for predicting recurrence in breast cancer
Background/Aim: Circulating microRNAs (miRs) in blood have been highlighted as
diagnostic, prognostic and predictive biomarkers for “Precision medicine”. This study aimed …
diagnostic, prognostic and predictive biomarkers for “Precision medicine”. This study aimed …
Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the …
L Guo, Z Dong, X Zhang, Y Yang, X Hu, Y Ji, C Li… - Phytomedicine, 2023 - Elsevier
Backgroud Flavonoids have a variety of biological activities, such as anti-inflammation, anti-
tumor, anti-thrombosis and so on. Morusinol, as a novel isoprene flavonoid extracted from …
tumor, anti-thrombosis and so on. Morusinol, as a novel isoprene flavonoid extracted from …
A novel thinking: DDR axis refines the classification of ccRCC with distinctive prognosis, multi omics landscape and management strategy
A Jiang, J Song, X Fang, Y Fang, Z Wang… - Frontiers in Public …, 2022 - frontiersin.org
Background DNA damage response and repair (DDR) related signatures play an important
role in maintaining genome stability and other biological processes. It also affects the …
role in maintaining genome stability and other biological processes. It also affects the …
[HTML][HTML] SPOP regulates the DNA damage response and lung adenocarcinoma cell response to radiation
Y Dong, D Zhang, M Cai, Z Luo, Y Zhu… - American journal of …, 2019 - ncbi.nlm.nih.gov
Speckle-type POZ protein (SPOP) plays an important role in maintaining genome stability.
Disability or mutation of the SPOP gene has been reported to contribute to prostate cancer …
Disability or mutation of the SPOP gene has been reported to contribute to prostate cancer …
Spatio-temporal changes in glutathione and thioredoxin redox couples during ionizing radiation-induced oxidative stress regulate tumor radio-resistance
Ionizing radiation (IR)-induced oxidative stress in tumor cells is effectively managed by
constitutive and inducible antioxidant defense systems. This study was initiated to …
constitutive and inducible antioxidant defense systems. This study was initiated to …
Molecular pathways: targeting DNA repair pathway defects enriched in metastasis
NM Corcoran, MJ Clarkson, R Stuchbery… - Clinical Cancer …, 2016 - AACR
The maintenance of a pristine genome, free from errors, is necessary to prevent cellular
transformation and degeneration. When errors in DNA are detected, DNA damage repair …
transformation and degeneration. When errors in DNA are detected, DNA damage repair …
Prognostic value of DNA damage response genomic alterations in relapsed/advanced urothelial cancer
Background DNA damage response (DDR) genomic alterations may play an important role
in clinical outcomes of patients with urothelial cancer (UC). However, data on the prognostic …
in clinical outcomes of patients with urothelial cancer (UC). However, data on the prognostic …
Design, synthesis and evaluation of phthalazinone thiohydantoin-based derivative as potent PARP-1 inhibitors
Y Zhong, Y Meng, X Xu, L Zhao, Z Li, Q You, J Bian - Bioorganic chemistry, 2019 - Elsevier
Two new series of compounds were designed and synthesized as potent PARP-1 inhibitors.
These compounds were evaluated for PARP-1 enzyme and cellular inhibitory activities. All …
These compounds were evaluated for PARP-1 enzyme and cellular inhibitory activities. All …
[HTML][HTML] Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer
N Alsubhi, F Middleton, TMA Abdel-Fatah… - Molecular Oncology, 2016 - Elsevier
Radiation-induced DNA damage activates the DNA damage response (DDR). DDR up-
regulation may predict radio-resistance and increase the risk of early local recurrence …
regulation may predict radio-resistance and increase the risk of early local recurrence …
Tampering of viruses and bacteria with host DNA repair: Implications for cellular transformation
Simple Summary A large number of DNA damages occur per cell every day due to several
causes, including viral and bacterial infections. The majority of them are repaired, but in …
causes, including viral and bacterial infections. The majority of them are repaired, but in …