Powassan Viruses Spread Cell to Cell during Direct Isolation from Ixodes Ticks and Persistently Infect Human Brain Endothelial Cells and Pericytes

JN Conde, S Sanchez-Vicente, N Saladino… - Journal of …, 2022 - Am Soc Microbiol
Powassan viruses (POWVs) are neurovirulent tick-borne flaviviruses emerging in the
northeastern United States, with a 2% prevalence in Long Island (LI) deer ticks (Ixodes …

Prevalence of Powassan Virus Seropositivity Among People with History of Lyme Disease and Non-Lyme Community Controls in the Northeastern United States

T Kapoor, L Murray, M Kuvaldina, CS Jiang… - Vector-Borne and …, 2024 - liebertpub.com
Introduction: Lyme disease (LD) affects∼ 476,000 people each year in the United States.
Symptoms are variable and include rash and flu-like symptoms. Reasons for the wide …

A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis

RM Broeckel, F Feldmann, KL McNally… - PLoS …, 2021 - journals.plos.org
Kyasanur Forest disease virus (KFDV) and the closely related Alkhurma hemorrhagic
disease virus (AHFV) are emerging flaviviruses that cause severe viral hemorrhagic fevers …

Powassan virus: a tick borne flavivirus infecting humans

X Yang, GF Gao, WJ Liu - Biosafety and Health, 2022 - mednexus.org
Infection of humans by Powassan virus (POWV) occurs rarely but is potentially life-
threatening. First isolated in Ontario, Canada in 1958, the presence of POWV has been …

A virus-like particle-based vaccine candidate against the tick-borne powassan virus induces neutralizing antibodies in a mouse model

V Cimica, S Saleem, E Matuczinski, D Adams-Fish… - Pathogens, 2021 - mdpi.com
Powassan virus (POWV) is a tick-borne flavivirus circulating in North America and the
Russian Far East that can cause severe neuroinvasive diseases, including encephalitis …

Cross-reactive antibodies in tick-borne encephalitis: case report and literature review

T Vilibic-Cavlek, T Ferenc, M Vujica Ferenc… - Antibodies, 2022 - mdpi.com
Flaviviruses are a heterogeneous group of viruses that may induce broad antigenic cross-
reactivity. We present a patient who was admitted to the infectious disease department with …

Can modern molecular modeling methods help find the area of potential vulnerability of flaviviruses?

DV Shanshin, SS Borisevich, AA Bondar… - International journal of …, 2022 - mdpi.com
Flaviviruses are single-stranded RNA viruses that have emerged in recent decades and
infect up to 400 million people annually, causing a variety of potentially severe …

Protein footprinting by mass spectrometry: H/D exchange, specific amino acid labeling, and fast photochemical oxidation of proteins

R Kant, AB Moyle, PN Jethva, ML Gross - Advanced spectroscopic methods …, 2023 - Elsevier
An emerging approach for analyzing protein structure is mass spectrometry-based
footprinting. Here, a footprint is installed within a protein by executing a chemical reaction …

Building Resilient Immunity Against Powassan Virus: The Necessity of A Comprehensive Immunoinformatic Approach and Coordinated T and B Cell Responses

S Beigh - Egyptian Academic Journal of Biological Sciences. C …, 2023 - journals.ekb.eg
Background: Powassan virus (POWV), a vector-borne pathogen primarily impacting humans
as incidental hosts, has recently surfaced as a significant worldwide health concern, carrying …

Age-dependent Powassan Virus Lethality and Neuropathogenesis in Mice

MC Mladinich, GE Himmler, JN Conde, EE Gorbunova… - bioRxiv, 2023 - biorxiv.org
Powassan viruses (POWV) are emergent tick-borne flaviviruses that cause severe
neurologic disease in humans. Subcutaneous inoculation of C57BL/6 mice with POWV …