Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
Single-cell RNA sequencing in cardiovascular development, disease and medicine
Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …
have had a transformative effect on biomedical research, enabling the profiling and analysis …
[HTML][HTML] A transcription factor atlas of directed differentiation
Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they …
processes and cell states. To comprehensively understand TFs and the programs they …
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function
LI Wang, P Yu, B Zhou, J Song, Z Li, M Zhang… - Nature cell …, 2020 - nature.com
Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed
characterization of the human heart is necessary; however, this has been largely impeded …
characterization of the human heart is necessary; however, this has been largely impeded …
Human iPSC-derived cardiomyocytes are susceptible to SARS-CoV-2 infection
Summary Coronavirus disease 2019 (COVID-19) is a pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is defined by respiratory …
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is defined by respiratory …
In situ expansion, differentiation, and electromechanical coupling of human cardiac muscle in a 3D bioprinted, chambered organoid
Rationale: One goal of cardiac tissue engineering is the generation of a living, human pump
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …
[HTML][HTML] Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids
During embryogenesis, paracrine signaling between tissues in close proximity contributes to
the determination of their respective cell fate (s) and development into functional organs …
the determination of their respective cell fate (s) and development into functional organs …
A comprehensive survey of regulatory network inference methods using single cell RNA sequencing data
Gene regulatory network is a complicated set of interactions between genetic materials,
which dictates how cells develop in living organisms and react to their surrounding …
which dictates how cells develop in living organisms and react to their surrounding …
Single-cell transcriptomics for the assessment of cardiac disease
AMA Miranda, V Janbandhu, H Maatz… - Nature Reviews …, 2023 - nature.com
Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
Patient and disease–specific induced pluripotent stem cells for discovery of personalized cardiovascular drugs and therapeutics
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …