The complexity of Alzheimer's disease: an evolving puzzle
The history of Alzheimer's disease (AD) started in 1907, but we needed to wait until the end
of the century to identify the components of pathological hallmarks and genetic subtypes and …
of the century to identify the components of pathological hallmarks and genetic subtypes and …
Epigenetic age prediction
DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.
Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …
development, although existing evidence for this varies. We present a meta-analysis and …
DNA methylation predicts age and provides insight into exceptional longevity of bats
Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up
Biological age measurements (BAs) assess aging-related physiological change and predict
health risks among individuals of the same chronological age (CA). Multiple BAs have been …
health risks among individuals of the same chronological age (CA). Multiple BAs have been …
Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …
morbidity and mortality making vaccination a crucial mean to safeguard this population …
[HTML][HTML] Epigenetic mechanisms of longevity and aging
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …
[HTML][HTML] Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging …
outcomes, yet there is a need for studies that examine their relationship to molecular aging …
Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer
H Luo, Q Zhao, W Wei, L Zheng, S Yi, G Li… - Science translational …, 2020 - science.org
Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …