In this review, the potential causes of ageing are discussed. We seek to gain insight into the
main physiological functions of mitochondria and discuss alterations in their function and the …

Skin aging appears to be the result of two overlapping processes, intrinsic and extrinsic. It is
well accepted that oxidative stress contributes significantly to extrinsic skin aging, although …

Acetylation of proteins on lysine residues is a dynamic posttranslational modification that is
known to play a key role in regulating transcription and other DNA-dependent nuclear …

Enhancing Human Capacities Enhancing Human Capacities Page 2 Enhancing Human
Capacities Edited by Julian Savulescu, Ruud ter Meulen, and Guy Kahane Page 3 This edition …

What is the neurocognitive basis for the considerable individual differences observed in
functioning of the adult mind and brain late in life? We review the evidence that in healthy …

The field of the “epidemiology of longevity” has been expanding rapidly in recent years.
Several long-term cohort studies have followed older adults long enough to identify the most …

Inflammation is associated with DNA damage, cellular senescence, and aging. Cessation of
the inflammatory cytokine response is mediated in part through cytokine mRNA degradation …

Background Family studies and heritability estimates provide evidence for a genetic
contribution to variation in the human life span. Methods We conducted a genome wide …

Previous studies have reported that shorter mean telomere length in lymphocytes was
associated with increased susceptibility to common diseases of aging, and may be …

Aging is the major biomedical challenge of this century. The percentage of elderly people,
and consequently the incidence of age-related diseases such as heart disease, cancer, and …