Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

There is strong evidence that most individuals in the elderly population are characterized by
inflamm‐aging which refers to a subtle increase in the systemic pro‐inflammatory …

Background: The relationship between dietary carbohydrate intake and serum Klotho levels,
an aging biomarker, remains uncertain. Objective: This study aimed to investigate the …

Pentadecanoic acid (C15: 0) is an essential odd-chain saturated fatty acid with broad
activities relevant to protecting cardiometabolic, immune, and liver health. C15: 0 activates …

Healthy aging is an integrated “whole person” process that involves an individual's biology,
behavior, and social/physical environment. With the recent development of antiaging drugs …

Abstract Background Ultraprocessed foods (UPFs) and poor diet quality have been
associated with frailty but existing studies had relatively short follow-up time. It is also …

Understanding the mechanisms of geroprotective interventions is central to aging research.
We compare four prominent interventions: senolysis, caloric restriction, in vivo partial …

In this study, we investigated the impact of the uremic toxin indoxyl sulfate on macrophages
and tubular epithelial cells and its role in modulating the response to lipopolysaccharide …

Human genomic analysis and genome-wide association studies (GWAS) have identified
genes that are risk factors for early and late-onset Alzheimer's disease (AD genes). Although …

Klotho is a beta-glucuronidase that reveals both anti-inflammatory and anti-oxidative
properties that have been associated with mechanisms of aging. The study aimed to analyze …