The microbiome plays a fundamental role in the maturation, function, and regulation of the
host-immune system from birth to old age. In return, the immune system has co-evolved a …

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …

Background The magnitude and durability of immune responses to coronavirus disease
2019 (COVID-19) mRNA vaccines remain incompletely characterized in the elderly …

Introduction of vaccines against COVID-19 has provided the most promising chance to
control the world-wide COVID-19 pandemic. However, the adenovirus-vector based …

Non-specific protective effects of certain vaccines have been reported, and long-term
boosting of innate immunity, termed trained immunity, has been proposed as one of the …

Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain
incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 …

Background: Prior studies have found a reduced risk of dementia of any etiology following
influenza vaccination in selected populations, including veterans and patients with serious …

As the thymus involutes during aging, the T‐cell pool has to be maintained by the periodic
expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of …

Background Novel mRNA-based vaccines have been used to protect against SARS-CoV-2,
especially in vulnerable populations who also receive an annual influenza vaccination. The …