Effective screening modalities are currently available for only a small subset of cancers, and
they generally have suboptimal performance with complicated procedures. Therefore, there …

Angiogenesis is a hallmark of cancer and is required for tumor growth and progression.
Antiangiogenic therapy has been revolutionarily developing and was approved for the …

Importance Detection of molecular residual disease and risk stratification as early as
possible may improve the treatment of patients with cancer. Efficient pragmatic tests are …

DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale international …

Major depressive disorder (MDD) is a prevalent and devastating mental illness. To date, the
diagnosis of MDD is largely dependent on clinical interviews and questionnaires and still …

Introduction Most patients with pancreatic cancer present with advanced stage, incurable
disease. However, patients with high-grade precancerous lesions and many patients with …

Colorectal cancer (CRC) develops mainly from colorectal advanced adenomas (AA), which
are considered precancerous lesions. Novel early diagnostic biomarkers are urgently …

This study was performed to characterize the metabolic alteration of non–small‐cell lung
cancer (NSCLC) and discover blood‐based metabolic biomarkers relevant to lung cancer …

Liquid biopsy assays for minimal residual disease (MRD) are used to monitor and inform
oncological treatment and predict the risk of relapse in cancer patients. To-date, most MRD …