DNA cytosine methylation (5-methylcytosine, 5mC) is a predominant epigenetic modification
that plays a critical role in a variety of biological and pathological processes in mammals. In …

To build health equity for an aging world marked by dramatic disparities in healthy lifespan
between countries, regions and population groups, research at the intersections of biology …

Background: DNA methylation (DNAm) may play a critical role in bridging prenatal adverse
events and cardiometabolic disorders including hypertension in later life. Methods: We …

Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

Background Epigenetic processes are fast emerging as a promising molecular system in the
search for both biomarkers and mechanisms underlying human health and disease risk …

Epigenetic researchers often evaluate DNA methylation as a potential mediator of the effect
of social/environmental exposures on a health outcome. Modern statistical methods for …

Background DTL has been found to be related with multiple cancers. However,
comprehensive analyses, which identify the prediction value of DTL in diagnosis, prognosis …

Background Climate change caused an increase in ambient temperature in the past
decades. Exposure to high ambient temperature could result in biological aging, but relevant …

Background Preterm birth is closely associated with a phenotype that includes brain
dysmaturation and neurocognitive impairment, commonly termed Encephalopathy of …

Gastric cancer (GC) represents a significant burden of cancer-related mortality worldwide,
underscoring an urgent need for the development of early detection strategies and precise …