The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …

Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome
transit along a given mRNA can influence nascent chain folding, but the extent to which …

A genome-scale genetic interaction map was constructed by examining 5.4 million gene-
gene pairs for synthetic genetic interactions, generating quantitative genetic interaction …

The function of RNA is subtly modulated by post-transcriptional modifications. Here, we
report an important crosstalk in the covalent modification of two classes of RNAs. We …

Iron-sulfur (Fe/S) proteins are involved in a wide variety of cellular processes such as
enzymatic reactions, respiration, cofactor biosynthesis, ribosome biogenesis, regulation of …

The generation of cortical projection neurons relies on the coordination of radial migration
with branching. Here, we report that the multisubunit histone acetyltransferase Elongator …

Protein translation is an energetically demanding process that must be regulated in
response to changes in nutrient availability. Herein, we report that intracellular methionine …

The cerebral cortex contains layers of neurons sequentially generated by distinct lineage-
related progenitors. At the onset of corticogenesis, the first-born progenitors are apical …

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support
cancer progression and metastasis. Posttranscriptional modifications of transfer RNAs …