Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

A growing body of evidence has emerged demonstrating a pathological link between
oxidative stress and schizophrenia. This evidence identifies oxidative stress as a …

Epidemiological studies have provided evidence that traffic noise exposure is linked to
cardiovascular diseases such as arterial hypertension, myocardial infarction, and stroke …

The discovery of proper molecular signature from OMIC data is indispensable for
determining biological state, physiological condition, disease etiology, and therapeutic …

Environmental risk factors, including noise, air pollution, chemical agents, ultraviolet
radiation (UVR) and mental stress have a considerable impact on human health. Oxidative …

Focus on the Warburg effect, initially descriptive of increased glycolysis in cancer cells, has
served to illuminate mitochondrial function in many other pathologies. This review explores …

Environmental noise is a well‐recognized health risk and part of the external exposome—
the World Health Organization estimates that 1 million healthy life years are lost annually in …

Global epidemiological studies show that chronic non-communicable diseases such as
atherosclerosis and metabolic disorders represent the leading cause of premature mortality …

The global concept of oxidative stress is defined as “an imbalance between oxidants and
antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …