We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to
validate biomarkers for Alzheimer's disease (AD) clinical trials. To improve generalizability …

The aim of this study was to determine whether the TAR DNA-binding protein of 43 kDa
(TDP-43) has any independent effect on the clinical and neuroimaging features typically …

Intracellular inclusions consisting of TAR DNA binding protein‐43 (TDP‐43 pathology) are
present in up to 57% of Alzheimer's disease (AD) cases and follow a distinct topographical …

Abstracts TAR DNA-binding protein 43 (TDP43) is a focus of research in late-onset
dementias. TDP43 pathology in the brain was initially identified in amyotrophic lateral …

The pathology-based classification of Alzheimer's disease (AD) and other
neurodegenerative diseases is a work in progress that is important for both clinicians and …

Objective: To examine frequencies and relationships of 5 common neuropathologic
abnormalities identified at autopsy with late-life cognitive impairment and dementia in 2 …

Abstract The Alzheimer's Association's Research Roundtable met in November 2017 to
explore the new National Institute on Aging and the Alzheimer's Association Research …

Over time, reduced hippocampal volume results in an amnestic syndrome, a core feature of
Alzheimer's disease. 1 Damage to the hippocampus is incorporated into the pathological …

Hippocampal sclerosis of aging (HS-A) is a common age-related neuropathological lesion
characterized by neuronal loss and astrogliosis in subiculum and CA1 subfield of …