Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …

Since the discovery of transposons, their sheer abundance in host genomes has puzzled
many. While historically viewed as largely harmless 'parasitic'DNAs during evolution …

Within the life cycle of a living organism, another life cycle exists for the selfish genome
inhabitants, which are called transposable elements (TEs). These mobile sequences invade …

The vertebrate genome is under constant threat of invasion by genetic parasites. Whether
the host can immediately recognize and respond to invading elements has been unclear …

Histones and associated chromatin proteins have essential functions in eukaryotic genome
organization and regulation. Despite this fundamental role in eukaryotic cell biology, we lack …

Adaptive immunity in jawed vertebrates relies on the assembly of antigen receptor genes by
the recombination activating gene 1 (RAG1)–RAG2 (collectively RAG) recombinase in a …

Wild animals and plants have developed a variety of adaptive traits driven by adaptive
evolution, an important strategy for species survival and persistence. Uncovering the …

There is considerable interest in understanding the effect of transposable elements (TEs) on
embryonic development. Studies in humans and mice are limited by the difficulty of working …