[HTML][HTML] The sound of silence: mechanisms and implications of HUSH complex function

M Seczynska, PJ Lehner - Trends in Genetics, 2023 - cell.com
The vertebrate genome is under constant threat of invasion by genetic parasites. Whether
the host can immediately recognize and respond to invading elements has been unclear …

Take a walk on the KRAB side

O Rosspopoff, D Trono - Trends in Genetics, 2023 - cell.com
Canonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as
major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the …

[HTML][HTML] The evolution of aging and lifespan

S Li, JM Vazquez, PH Sudmant - Trends in Genetics, 2023 - cell.com
Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

[HTML][HTML] Transposable elements: major players in shaping genomic and evolutionary patterns

N Colonna Romano, L Fanti - Cells, 2022 - mdpi.com
Transposable elements (TEs) are ubiquitous genetic elements, able to jump from one
location of the genome to another, in all organisms. For this reason, on the one hand, TEs …

[HTML][HTML] Autonomous transposons tune their sequences to ensure somatic suppression

İA Ilık, P Glažar, K Tse, B Brändl, D Meierhofer… - Nature, 2024 - nature.com
Transposable elements (TEs) are a major constituent of human genes, occupying
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …

Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions

S Jacquet, M Culbertson, C Zhang, A El Filali… - Science …, 2022 - science.org
Several bat species act as asymptomatic reservoirs for many viruses that are highly
pathogenic in other mammals. Here, we have characterized the functional diversification of …

The evolution and role of eukaryotic-like domains in environmental intracellular bacteria: the battle with a eukaryotic cell

JE Martyn, L Gomez-Valero… - FEMS Microbiology …, 2022 - academic.oup.com
Intracellular pathogens that are able to thrive in different environments, such as Legionella
spp. that preferentially live in protozoa in aquatic environments or environmental …

[HTML][HTML] A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease

F Macciardi, M Giulia Bacalini, R Miramontes… - GeroScience, 2022 - Springer
Recent reports have suggested that the reactivation of otherwise transcriptionally silent
transposable elements (TEs) might induce brain degeneration, either by dysregulating the …

The 3D-Evo space: evolution of gene expression and alternative splicing regulation

F Mantica, M Irimia - Annual Review of Genetics, 2022 - annualreviews.org
Animal species present relatively high levels of gene conservation, and yet they display a
great variety of cell type and tissue phenotypes. These diverse phenotypes are mainly …

[HTML][HTML] Long-read direct RNA sequencing reveals epigenetic regulation of chimeric gene-transposon transcripts in Arabidopsis thaliana

J Berthelier, L Furci, S Asai, M Sadykova… - Nature …, 2023 - nature.com
Transposable elements (TEs) are accumulated in both intergenic and intragenic regions in
plant genomes. Intragenic TEs often act as regulatory elements of associated genes and are …