Cancer is characterized by abnormal cell differentiation in or on the part of the body. The
most commonly used chemotherapeutic drugs are developed to target rapidly dividing cells …

Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …

Fluorinated nucleosides and oligonucleotides are of specific interest as probes for studying
nucleic acids interaction, structures, biological transformations, and its biomedical …

Peptide nucleic acids (PNA) are synthetic nucleic acid analogues with a neutral N-(2-
aminoethyl) glycine backbone. PNA possess unique physicochemical characteristics such …

Selective incorporation of conformational constraints into thyclotides can be used to
modulate their binding to complementary oligonucleotides, increase polarity, and optimize …

Gene-editing technologies have revolutionized biotechnology, but current gene editors
suffer from several limitations. Here, we harnessed the power of gamma-modified peptide …

Herein, peptide nucleic acids (PNAs) are employed in the design of a participatory duplex
PNA‐peptide crosslinking agent. Biophysical and mechanical studies show that crosslinkers …

RNA folding is driven by the formation of double-helical segments interspaced by loops of
unpaired nucleotides. Among the latter, bulges formed by one or several unpaired …

LNA-containing oligonucleotides bind DNA more tightly than standard DNA, so they can
interact with targeted sequences and affect multiple processes. When a desired DNA is …

Peptide nucleic acid (PNA) is a nucleic acid mimic with high specificity and binding affinity to
natural DNA or RNA, as well as resistance to enzymatic degradation. PNA sequences can …