[HTML][HTML] Epigenetic reprogramming as a key to reverse ageing and increase longevity
B Pereira, FP Correia, IA Alves, M Costa… - Ageing research …, 2024 - Elsevier
The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …
DNA methylation as a tool to explore ageing in wild roe deer populations
DNA methylation‐based biomarkers of ageing (epigenetic clocks) promise to lead to new
insights into evolutionary biology of ageing. Relatively little is known about how the natural …
insights into evolutionary biology of ageing. Relatively little is known about how the natural …
[HTML][HTML] Impact of air pollution on cardiovascular aging
The world population is aging rapidly, and by some estimates, the number of people older
than 60 will double in the next 30 years. With the increase in life expectancy, adverse effects …
than 60 will double in the next 30 years. With the increase in life expectancy, adverse effects …
Epimutations define a fast-ticking molecular clock in plants
N Yao, RJ Schmitz, F Johannes - Trends in Genetics, 2021 - cell.com
Stochastic gains and losses of DNA methylation at CG dinucleotides are a frequent
occurrence in plants. These spontaneous 'epimutations' occur at a rate that is 100 000 times …
occurrence in plants. These spontaneous 'epimutations' occur at a rate that is 100 000 times …
Epigenetic predictors of species maximum life span and other life-history traits in mammals
By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation
(DNAm) predictors of maximum life span (R= 0.89), gestation time (R= 0.96), and age at …
(DNAm) predictors of maximum life span (R= 0.89), gestation time (R= 0.96), and age at …
Lifespan extension in long-lived vertebrates rooted in ecological adaptation
O Omotoso, VN Gladyshev, X Zhou - Frontiers in Cell and …, 2021 - frontiersin.org
Contemporary studies on aging and longevity have largely overlooked the role that
adaptation plays in lifespan variation across species. Emerging evidence indicates that the …
adaptation plays in lifespan variation across species. Emerging evidence indicates that the …
DNA methylation entropy as a measure of stem cell replication and aging
Background Epigenetic marks are encoded by DNA methylation and accumulate errors as
organisms age. This drift correlates with lifespan, but the biology of how this occurs is still …
organisms age. This drift correlates with lifespan, but the biology of how this occurs is still …
Big brown bats experience slower epigenetic ageing during hibernation
IR Sullivan, DM Adams, LJS Greville… - … of the Royal …, 2022 - royalsocietypublishing.org
Comparative analyses of bats indicate that hibernation is associated with increased
longevity among species. However, it is not yet known if hibernation affects biological …
longevity among species. However, it is not yet known if hibernation affects biological …
Serum proteomics reveals a tolerant immune phenotype across multiple pathogen taxa in wild vampire bats
Bats carry many zoonotic pathogens without showing pronounced pathology, with a few
exceptions. The underlying immune tolerance mechanisms in bats remain poorly …
exceptions. The underlying immune tolerance mechanisms in bats remain poorly …
The evolution and ecology of oxidative and antioxidant status: a comparative approach in African mole-rats
The naked mole-rat of the family Bathyergidae has been the showpiece for ageing research
as they contradict the traditional understanding of the oxidative stress theory of ageing …
as they contradict the traditional understanding of the oxidative stress theory of ageing …