Bats carry many zoonotic pathogens without showing pronounced pathology, with a few
exceptions. The underlying immune tolerance mechanisms in bats remain poorly …

Contemporary studies on aging and longevity have largely overlooked the role that
adaptation plays in lifespan variation across species. Emerging evidence indicates that the …

Nucleosides are essential cornerstones of life, and nucleoside derivatives and synthetic
analogues have important biomedical applications. Correspondingly, production of non …

Crustaceans are notoriously difficult to age because of their indeterminate growth and the
moulting of their exoskeleton throughout life. The poor knowledge of population age …

DNA methylation rates have previously been found to broadly correlate with maximum
lifespan in mammals, yet no precise relationship has been observed. We developed a …

DNA methylation is one of the epigenetic modifications of the genome, the essence of which
is the attachment of a methyl group to nitrogenous bases. In the eukaryote genome, cytosine …

Long life requires individuals to defend themselves against pathogens over prolonged
periods of time whilst minimising damage to themselves. In vertebrates, pathogen defence is …

To address how conserved DNA methylation-based epigenetic aging is in diverse branches
of the tree of life, we generated DNA methylation data from African clawed frogs (Xenopus …

We suggest that mammalian endothermy was established amongst Middle Jurassic crown
mammals, through reviewing state‐of‐the‐art fossil and living mammal studies. This is …

Motivation Epigenetic clocks are prediction methods based on DNA methylation levels in a
given species or set of species. Defined as multivariate regression models, these DNA …